|
|
5-formyltetrahydrofolate + ATP <=> 5,10-methenyltetrahydrofolate + ADP + phosphate
|
6.3.3.2
5-formyltetrahydrofolate cyclo-ligase
|
–
|
MK
|
|
BRENDA:
BR127;
BS453763
KEGG:
R02301
MetaCyc:
5-FORMYL-THF-CYCLO-LIGASE-RXN
SABIO-RK:
2263
|
|
|
|
5,10-methenyltetrahydrofolate + H2O <=> 10-formyltetrahydrofolate + H+
|
3.5.4.9
methenyltetrahydrofolate cyclohydrolase
|
–
|
BMK
|
|
BRENDA:
BR22746
KEGG:
R01655
MetaCyc:
METHENYLTHFCYCLOHYDRO-RXN
SABIO-RK:
74
|
|
|
|
5-formimidoyltetrahydrofolate + H+ <=> NH3 + 5,10-methenyltetrahydrofolate
|
4.3.1.4
formimidoyltetrahydrofolate cyclodeaminase
|
–
|
BMK
|
|
BRENDA:
BR3426
KEGG:
R02302
MetaCyc:
4.3.1.4-RXN
SABIO-RK:
2264
|
|
|
|
5,10-methylenetetrahydrofolate + NAD+ <=> 5,10-methenyltetrahydrofolate + NADH
|
1.5.1.15
methylenetetrahydrofolate dehydrogenase (NAD+)
1.5.1.5
methylenetetrahydrofolate dehydrogenase (NADP+)
|
–
–
|
MK
|
|
BRENDA:
BR36891
KEGG:
R01218
MetaCyc:
1.5.1.15-RXN
SABIO-RK:
1450
|
|
|
|
5,10-methylenetetrahydrofolate + NADP+ <=> 5,10-methenyltetrahydrofolate + NADPH
|
1.5.1.15
methylenetetrahydrofolate dehydrogenase (NAD+)
1.5.1.5
methylenetetrahydrofolate dehydrogenase (NADP+)
|
–
–
|
BMK
|
|
BRENDA:
BR36902;
BS454753
KEGG:
R01220
MetaCyc:
METHYLENETHFDEHYDROG-NADP-RXN
SABIO-RK:
73
|
|
|
|
5,10-methenyltetrahydrofolate + H2O <=> 5-formyltetrahydrofolate + H+
|
2.1.2.10
aminomethyltransferase
3.5.4.9
methenyltetrahydrofolate cyclohydrolase
|
–
–
|
MK
|
|
BRENDA:
BS372118
KEGG:
R02300
MetaCyc:
RXN-6321
SABIO-RK:
2262
|
|
|
|
5''-Phosphoribosylglycinamide + 5,10-methenyltetrahydrofolate + H2O <=> 5''-Phosphoribosyl-N-formylglycinamide + tetrahydrofolate
|
2.1.2.2
phosphoribosylglycinamide formyltransferase
|
–
|
K
|
|
KEGG:
R04326
|
|
|
|
sarcosine + oxidized_electron_transfer_flavoprotein + tetrahydrofolate + H+ <=> glycine + 5,10-methenyltetrahydrofolate + reduced_flavodoxin
|
1.5.8
|
–
|
M
|
|
MetaCyc:
RXN66-577
|
|
|
|
5,10-methenyltetrahydrofolate + FADH2 <=> 5,10-methylenetetrahydrofolate + FAD
|
1.5.8.4
dimethylglycine dehydrogenase
|
–
|
|
|
BRENDA:
BS370811
|
|
|
|
5,10-methenyltetrahydrofolate_glutamate + H2O <=> 5,10-methenyltetrahydrofolate + L-glutamate
|
3.4.19.9
folate gamma-glutamyl hydrolase
|
–
|
|
|
BRENDA:
BS431421
|
|
|
|
5,10-methenyltetrahydrofolate_heptaglutamate + 7 H2O <=> 5,10-methenyltetrahydrofolate + 7 L-glutamate
|
3.4.19.9
folate gamma-glutamyl hydrolase
|
–
|
|
|
BRENDA:
BS431422
|
|
|
|
5,10-methenyltetrahydrofolate_hexaglutamate + 6 H2O <=> 5,10-methenyltetrahydrofolate + 6 L-glutamate
|
3.4.19.9
folate gamma-glutamyl hydrolase
|
–
|
|
|
BRENDA:
BS431423
|
|
|
|
L-5,10-methylenetetrahydrofolate + NAD+ <=> 5,10-methenyltetrahydrofolate + NADH
|
1.5.1.15
methylenetetrahydrofolate dehydrogenase (NAD+)
|
–
|
|
|
BRENDA:
BS259208
|
|
|
|
5,10-methenyltetrahydrofolate + dUMP <=> 7,8-dihydrofolate + dTMP
|
2.1.1.45
thymidylate synthase
|
–
|
|
|
BRENDA:
BS399200
|
|
|
|
CTP + 5-formyltetrahydrofolate <=> CDP + phosphate + 5,10-methenyltetrahydrofolate
|
6.3.3.2
5-formyltetrahydrofolate cyclo-ligase
|
–
|
|
|
BRENDA:
BS453764
|
|
|
|
UTP + 5-formyltetrahydrofolate <=> UDP + phosphate + 5,10-methenyltetrahydrofolate
|
6.3.3.2
5-formyltetrahydrofolate cyclo-ligase
|
–
|
|
|
BRENDA:
BS453765
|
|
|
|
5,10-methenyltetrahydrofolate + beta-glycinamide_ribonucleotide + H2O <=> 10-formyltetrahydrofolate + formylglycinamide_ribonucleotide
|
2.1.2.2
phosphoribosylglycinamide formyltransferase
|
–
|
|
|
BRENDA:
BS320044
|
|
|
|
5,10-methenyltetrahydrofolate + beta-glycinamide_ribonucleotide <=> N10-formyltetrahydropteroylglutamate + formylglycinamide_ribonucleotide
|
2.1.2.3
phosphoribosylaminoimidazolecarboxamide formyltransferase
|
–
|
|
|
BRENDA:
BS320060
|
|
|
|
5,10-methenyltetrahydrofolate + reduced_N,N-dimethylglycine <=> 5,10-methylenetetrahydrofolate + oxidized_N,N-dimethylglycine
|
1.5.3.10
dimethylglycine oxidase
|
–
|
|
|
BRENDA:
BS372117
|
|
|
|
5,10-methenyltetrahydrofolate + 2-amino-N-ribosylacetamide_5''-phosphate + H2O <=> formylglycinamide_ribonucleotide + tetrahydrofolate + 2-formamido-N-ribosylacetamide_5''-phosphate
|
2.1.2.2
phosphoribosylglycinamide formyltransferase
|
–
|
|
|
BRENDA:
BS320043
|
|
|
|
5,10-methenyltetrahydrofolate + H2O <=> 10-formyltetrahydrofolate + H+ + methanol
|
3.5.4.9
methenyltetrahydrofolate cyclohydrolase
|
–
|
|
|
BRENDA:
BS141116
|
|